Bristles induce bracts via the EGFR pathway on Drosophila legs
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Bristles induce bracts via the EGFR pathway on Drosophila legs
A long-standing mystery in Drosophila has been: how do certain bristles induce adjacent cells to make bracts (a type of thick hair) on their proximal side? The apparent answer, based on loss- and gain-of-function studies, is that they emit a signal that neighbors then transduce via the epidermal growth factor receptor pathway. Suppressing this pathway removes bracts, while hyperactivating it ev...
متن کاملSpitz/EGFr signalling via the Ras/MAPK pathway mediates the induction of bract cells in Drosophila legs.
In the development of Drosophila, the activation of the EGFr pathway elicits different cellular responses at different times and in different tissues. A variety of approaches have been used to identify the mechanisms that confer this response specificity. We have analysed the specification of bract cells in Drosophila legs. We observed that mechanosensory bristles induced bract fate in neighbou...
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INTRODUCTION M U C H of the geometrical complexity of animals and plants arises by the repetition of similar structures, often in a pattern which is constant for a species. In an earlier paper (Maynard Smith, 1960) some of the mechanisms whereby a constant number of structures in a linear series might arise were discussed. In this paper an attempt is made to extend the argument to cases where s...
متن کاملVariation of Scutellar Bristles in Drosophila
HE prime questions posed in genetic research are “what is the gene and how does it act to affect the phenotype” with much less attention given to the questions “what is the genotype and how does it determine the phenotype”. Geneticists interested in the genetic basis of continuously varying characters have to a large degree been involved in the second approach, attempting to describe the nature...
متن کاملVariation of Scutellar Bristles in Drosophila
UANTAL differences (key characters) have played a major role in syste0 matics, and, although there has been a great deal of discussion of the role of such quantal characters in speciation, there have been very few attempts to analyze the genetic basis of phenotypic constancy. The assumption that such phenotypic constancy is diagnostic of genetic constancy has been shown to be invalid for a rang...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2002
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(02)00212-5