Brinkley-Fest of Mitosis

Telomere Replication: An Est Fest

The search for subunits of the telomerase enzyme has uncovered orthologs of the budding years Est1 protein in several species, including humans. Thus, positive regulation of telomerase by Est1 appears to be a widely utilized mechanism for maintaining telomere length homeostasis.

Convex and Combinatorial Geometry Fest

Karoly Bezdek and Egon Schulte are two geometers who have made important and numerous contributions to Discrete Geometry. Both have trained many young mathematicians and have actively encouraged the development of the area by professors of various countries. Karoly Bezdek studied the illumination problem among many other problems about packing and covering of convex bodies. More recently he has...

The Three-Tier Architecture Pattern Language Design Fest

The biochemistry of mitosis.

In this article, we will discuss the biochemistry of mitosis in eukaryotic cells. We will focus on conserved principles that, importantly, are adapted to the biology of the organism. It is vital to bear in mind that the structural requirements for division in a rapidly dividing syncytial Drosophila embryo, for example, are markedly different from those in a unicellular yeast cell. Nevertheless,...

Modeling mitosis.

The mitotic spindle is a fascinating protein machine that uses bipolar arrays of dynamic microtubules and many mitotic motors to coordinate the accurate segregation of sister chromatids. Here we discuss recent mathematical models and computer simulations that, in concert with experimental studies, help explain the molecular mechanisms by which the spindle machinery performs its crucial function...