Bringing protein biomarker discovery to the clinic
نویسندگان
چکیده
منابع مشابه
Metabolomics for Biomarker Discovery: Moving to the Clinic
To improve the clinical course of diseases, more accurate diagnostic and assessment methods are required as early as possible. In order to achieve this, metabolomics offers new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biolo...
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Increased signaling through the phosphoinositide 3-kinase (PI3K)/AKT/ mammalian target of rapamycin (mTOR) pathway occurs in diverse malignancies. In cancer, the PI3K/AKT/mTOR pathway can be activated by mutations in several oncogenes such as PIK3CA, PIK3R1, AKT, TSC1/2, LKB1 and PTEN (Fig. 1). Most activating mutations occur in the helical or kinase domain of the PIK3CA gene. Preclinical model...
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ژورنال
عنوان ژورنال: Expert Review of Molecular Diagnostics
سال: 2009
ISSN: 1473-7159,1744-8352
DOI: 10.1586/erm.09.22