BrevicidineB, a New Member of the Brevicidine Family, Displays an Extended Target Specificity

Graphical Abstract The antimicrobial mode of action brevicidines. Brevicidines are potent cyclic lipopeptides active against Gram-negative pathogens. They have low hemolytic activity and cytotoxicity. BrevicidineB, a single amino acid residue mutant brevicidine, displays an altered spectrum, showing also Gram-positive Due to disruption the proton motive force pathogens, brevicidines act as bactericidal antibiotics. In addition, brevicidineB acts antibiotic because its capacity cellular membrane.