Breaking In: Human Metapneumovirus Fusion and Entry
نویسندگان
چکیده
منابع مشابه
Breaking In: Human Metapneumovirus Fusion and Entry
Human metapneumovirus (HMPV) is a leading cause of respiratory infection that causes upper airway and severe lower respiratory tract infections. HMPV infection is initiated by viral surface glycoproteins that attach to cellular receptors and mediate virus membrane fusion with cellular membranes. Most paramyxoviruses use two viral glycoproteins to facilitate virus entry-an attachment protein and...
متن کاملLow-pH triggering of human metapneumovirus fusion: essential residues and importance in entry.
Human metapneumovirus (HMPV) is a significant respiratory pathogen classified in the Pneumovirinae subfamily of the paramyxovirus family. Recently, we demonstrated that HMPV F protein-promoted cell-cell fusion is stimulated by exposure to low pH, in contrast to what is observed for other paramyxovirus F proteins. In the present study, we examined the potential role of histidine protonation in H...
متن کاملGlobal Genetic Diversity of Human Metapneumovirus Fusion Gene
We analyzed 64 human metapneumovirus strains from eight countries. Phylogenetic analysis identified two groups (A and B, amino acid identity 93%-96%) and four subgroups. Although group A strains predominated, accounting for 69% of all strains, as many B as A strains were found in persons >3 years of age.
متن کاملCharacterization of Iranian Avian Metapneumovirus based on Fusion Gene (F)
Avian metapneumovirus (aMPV) represents one of the most prevalent diseases of poultry mainly in combination with other pathogens, and it is increasing among chickens. In the present study, the detection and characterization of an aMPV subtype B strain circulating in broiler flocks based on fusion (F) gene. In phylogenetic analysis, the isolates are located in B subtype cl...
متن کاملHuman Metapneumovirus.
Human metapneumovirus (HMPV), a paramyxovirus identified in 2001, is a leading cause of respiratory tract infections in both children and adults. Seroprevalence studies demonstrate that the primary infection occurs before the age of 5 years, and humans are reinfected throughout life. The four subgroups of HMPV occur with year-to-year variability, and infection with one subgroup confers some ser...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Viruses
سال: 2013
ISSN: 1999-4915
DOI: 10.3390/v5010192