Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
نویسندگان
چکیده
منابع مشابه
Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: initial findings.
Prepulse inhibition (PPI) of the startle reflex is disrupted in a number of developmental neuropsychiatric disorders, including Tourette syndrome (TS). This disruption is hypothesized to reflect abnormalities in sensorimotor gating. We applied whole-brain functional magnetic resonance imaging (fMRI) to elucidate the neural correlates of PPI in adult TS subjects using airpuff stimuli to the thro...
متن کاملDoes angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice?
Changes in the levels of angiotensin-converting enzyme (ACE) have been found in brains of schizophrenia patients, suggesting a possible involvement of angiotensin in the illness. Prepulse inhibition (PPI) is a measure of sensorimotor gating and is disrupted in patients with schizophrenia. In a previous study, a reduction of ACE activity, either in ACE knockout mice or after ACE inhibitor treatm...
متن کاملThalamic Deep Brain Stimulation for Tourette Syndrome
L. Ackermansa, I. Neunerb, Y. Temela,c, A. Duitsd,e, J. Kuhnf and V. Visser-Vandewalleg,∗ Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Science, Maastricht, The Netherlands Depar...
متن کاملDeep Brain Stimulation for Tourette Syndrome
Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterised by motor and vocal tics. Tics often present early in childhood at 6-8 years old, commonly following a waxing and waning course before reaching a peak in severity at around 12 years of age [1]. Although symptoms can subside by early adulthood, a significant number of patients continue to experience severe tics across t...
متن کاملRandomized trial of behavior therapy for adults with Tourette syndrome.
CONTEXT Tics in Tourette syndrome begin in childhood, peak in early adolescence, and often decrease by early adulthood. However, some adult patients continue to have impairing tics. Medications for tics are often effective but can cause adverse effects. Behavior therapy may offer an alternative but has not been examined in a large-scale controlled trial in adults. OBJECTIVE To test the effica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Psychiatry Research: Neuroimaging
سال: 2013
ISSN: 0925-4927
DOI: 10.1016/j.pscychresns.2013.05.009