Brain-immune interactions in perinatal hypoxic-ischemic brain injury
نویسندگان
چکیده
منابع مشابه
Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury
Perinatal hypoxia-ischemia (HI) is an important cause of neonatal brain injury. Recent progress in the search for neuroprotective compounds has provided us with several promising drugs to reduce perinatal HI-induced brain injury. In the early stage (first 6 hours after birth) therapies are concentrated on prevention of the production of reactive oxygen species or free radicals (xanthine-oxidase...
متن کاملNeuroprotective Therapies after Perinatal Hypoxic-Ischemic Brain Injury
Hypoxic-ischemic (HI) brain injury is one of the main causes of disabilities in term-born infants. It is the result of a deprivation of oxygen and glucose in the neural tissue. As one of the most important causes of brain damage in the newborn period, the neonatal HI event is a devastating condition that can lead to long-term neurological deficits or even death. The pattern of this injury occur...
متن کاملHypoxic-Ischemic Brain Injury in Piglets
Background and Purpose: The excitatory amino acid inhibitor MK-801 has been shown in many animals species to protect against hypoxic-ischemic brain injury. We sought to determine whether hypoxic-ischemic injury to the newborn pig's brain could be prevented by the use of MK-801. Methods: Hypoxic-ischemic injury to the brain was induced in forty 0-3-day-old piglets. They were randomized to receiv...
متن کاملMannitol therapy in perinatal hypoxic-ischemic brain damage in rats.
To study the efficacy of mannitol in reducing cerebral edema and improving the ultimate neuropathologic outcome in perinatal cerebral hypoxia-ischemia, 67 7-day postnatal rats were subjected to unilateral common carotid artery ligation followed by exposure to 8% oxygen at 37 degrees C for 3 hours. Twenty-seven rat pups received a subcutaneous injection of 0.1 ml mannitol in a dosage of 4 mg/kg ...
متن کاملNeuroprotective effects of geneticin (G418) via apoptosis in perinatal hypoxic-ischemic brain injury
접수 : 2007년 12월 4일, 승인 : 2008년 1월 9일 이 연구는 2002년도 대구가톨릭대학교 의과학연구소 연구비의 지원으로 이루어졌음 책임저자 : 김우택, 대구가톨릭대학병원 소아과청소년과 Correspondence : Woo Taek Kim, M.D. Tel : 053)650-4250 Fax : 053)622-4240 E-mail : [email protected] xia at birth is estimates to be 0.2-0.4% in full-term newborn infants and approaches 60% in preterm infants. About 20-50% of infants suffering from H-I encephalopathy expire during the ...
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ژورنال
عنوان ژورنال: Progress in Neurobiology
سال: 2017
ISSN: 0301-0082
DOI: 10.1016/j.pneurobio.2017.10.006