Brain-Derived Neurotrophic Factor And Coronary Artery Disease

Coronary artery disease (CAD) is defined as myocardial damage developing a result of its organic and functional changes, leading to impaired blood flow through the coronary arteries. An important pathogenetic component CAD atherosclerosis. Currently, key aspects molecular relationship between inflammation atherosclerosis are being actively studied, immunometabolic theory discussed, along with an involvement perivascular adipose tissue in pathogenesis this pathology, due ability respond atherogenic stimuli via inflammatory reactions. Evidence has been accumulated that patients CAD, both their tissue, level neurotrophic factors (in particular, brain-derived factor, BDNF) which may be promising area research from standpoint studying factor therapeutic target for CAD. Neurotrophic growth control functioning immune nervous systems, balance energy metabolism innervation tissue. They affect vascular homeostasis, also involved causing stopping inflammation. there data on role BDNF cardiovascular, neurodegenerative metabolic diseases, effect polyunsaturated fatty acids eicosanoids and, accordingly, development progression Our review summarizes published (2019-2021) pathophysiological mechanisms (atherosclerosis).