BRAIN γ-AMINOBUTYRIC-α-KETOGLUTARIC TRANSAMINASE
نویسندگان
چکیده
منابع مشابه
Elevation of y=Aminobutyric Acid in Brain: Selective Inhibition of y-Aminobutyric-a-ketoglutaric Acid Transaminase*
The quantitative measurement of amino acids in different areas of the central nervous system has shown that a progressive increase takes place in levels of y-aminobutyric acid during development (2, 3), and that the concentration of this amino acid in adult brain is relatively constant under a variety of physiological stresses. y-Aminobutyric acid is synthesized by glutamic acid decarboxylase, ...
متن کاملPurification studies of tyrosine-alpha-ketoglutaric acid transaminase.
Recent studies in vitro of tyrosine metabolism have revealed the distribution and the r&e of the tyrosine-a-ketoglutaric acid transaminase system (l-8). In certain of these studies the obligatory rBle of this transaminase as a first step in the conversion of tyrosine to homogentisic acid has been indicated (6-S). The present study is concerned with the partial purification of dog liver tyrosine...
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Since the cloning of the first γ-aminobutyric acid (GABA) transporter (GAT1; SLC6A1) from rat brain in 1990, more than 50 published studies have provided structure-function information on investigator-designed rat and mouse GAT1 mutants. To date, more than 200 of 599 GAT1 residues have been subjected to mutagenesis experiments by substitution with different amino acids, and the resulting transp...
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INTRODUCTION Several neurodegenerative diseases are classified as proteopathies as they are associated with the aggregation of misfolded proteins. Synucleinopathies are a group of neurodegenerative disorders associated with abnormal deposition of synucleins. α-Synucleinopathies include Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Recently accumulation of another ...
متن کاملGenetic manipulation of the γ-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of γ-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kernels.
Gamma-aminobutyric acid (GABA) is a non-protein amino acid commonly present in all organisms. Because cellular levels of GABA in plants are mainly regulated by synthesis (glutamate decarboxylase, GAD) and catabolism (GABA-transaminase, GABA-T), we attempted seed-specific manipulation of the GABA shunt to achieve stable GABA accumulation in rice. A truncated GAD2 sequence, one of five GAD genes,...
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ژورنال
عنوان ژورنال: THE JOURNAL OF VITAMINOLOGY
سال: 1959
ISSN: 0022-5398
DOI: 10.5925/jnsv1954.5.117