Brain Alkalosis and Birth Asphyxia Seizures

Brain alkalosis causes birth asphyxia seizures, suggesting therapeutic strategy.

OBJECTIVE The mechanisms whereby birth asphyxia leads to generation of seizures remain unidentified. To study the possible role of brain pH changes, we used a rodent model that mimics the alterations in systemic CO(2) and O(2) levels during and after intrapartum birth asphyxia. METHODS Neonatal rat pups were exposed for 1 hour to hypercapnia (20% CO(2) in the inhaled gas), hypoxia (9% O(2)), ...

Acid extrusion via blood–brain barrier causes brain alkalosis and seizures after neonatal asphyxia

Birth asphyxia is often associated with a high seizure burden that is predictive of poor neurodevelopmental outcome. The mechanisms underlying birth asphyxia seizures are unknown. Using an animal model of birth asphyxia based on 6-day-old rat pups, we have recently shown that the seizure burden is linked to an increase in brain extracellular pH that consists of the recovery from the asphyxia-in...

Birth asphyxia.

Birth asphyxia and cerebral palsy

resection,2 and in Britain we may well be dealing mostly with patients whose disease has infiltrated into surrounding tissue. The early disease in Japan may be different from that in Britain because the survival in Japanese patients (95%) is so much better than that in British patients (70%) that it cannot be explained purely on the basis of removing more affected nodes-and even RI resection in...

“Risk factors of birth asphyxia”

BACKGROUND Birth asphyxia is an insult to the fetus or newborn due to failure to breath or breathing poorly, leads to decrease oxygen perfusion to various organs. According to WHO, 4 million neonatal deaths occurred each year due to birth asphyxia. Our goal was to evaluate antepartum, intrapartum, and fetal risk factors of birth asphyxia. METHODS It was a Retrospective Case control study, con...