Bradykinin stimulates bone resorption and lysosomal-enzyme release in cultured mouse calvaria

lysosomal-enzyme release in cultured mouse calvaria

The effect of bradykinin on bone resorption was studied in cultures of newbornmouse calvaria. Bradykinin (0.03,UM, 1 Mm) stimulated the release of 4'Ca2+ from bones dissected out from mice prelabelled in vivo with 45Ca. Bradykinin (1 Mm) also augmented the release of stable calcium (4"Ca), Pi and the lysosomal enzyme f,glucuronidase. The stimulatory effect of bradykinin on mineral mobilization ...

Cyclosporine A inhibits bone resorption in cultured neonatal mouse calvaria.

The effect of the immunosuppressive agent cyclosporine A (CsA) on the resorption of neonatal mouse calvaria was examined in vitro. CsA, at concentrations of 10(-7) to 3 X 10(-5) M, inhibited bone resorption produced by 10(-8) M parathyroid hormone, 3 U/ml of mouse recombinant interleukin-1,5 X 10(-7) M prostaglandin E2, 14 U/ml of thrombin, 5 micrograms/ml of bacterial lipopolysaccharide or 10(...

Rainbow Trout Hypocalcin Stimulates Bone Resorption in Embryonic Mouse Calvaria in Vitro in a Pth-like Fashion

Rainbow Trout Hypocalcin Stimulates Bone Resorption in Embryonic Mouse Calvaria in Vitro in a Pth-like Fashion

Rainbow Trout Hypocalcin Stimulates Bone Resorption in Embryonic Mouse Calvaria in Vitro in a Pth-like Fashion