Bradykinin: Natural and Synthetic Bradykinin
نویسندگان
چکیده
منابع مشابه
Biologically active synthetic fragments of bradykinin.
Bradykinin, Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, is released from bradykininogen by the action of kallikreins and brings about smooth muscle stimulation, vasodilation, increase in capillary permeability, ac cumulation and migration of leucocytes and pain production. It is well known that so-called kininase, for example catheptic carboxypeptidase B and carboxypeptidase N, destroy bradykinin by c...
متن کاملVascular and sympathoadrenal responses to bradykinin and a bradykinin analogue.
These experiments were designed to assess the interaction of bradykinin and its antagonist (Arg-Pro-Hyp-Gly-Phe-Ser-DPhe-Phe-Arg-trifluoroacetic acid) with the sympathoadrenal system. Three groups of male Wistar rats received 5-minute intra-arterial infusions of either dextrose (Group 1, n = 6), bradykinin, 250 micrograms/min (Group 2, n = 5), or bradykinin, 25 micrograms/min (Group 3, n = 4). ...
متن کاملGeneral and Regional Circulatory Effects of Synthetic Bradykinin in Man.
• Bradykinin is a potent vasodilator in several animal species. The circulatory effects of bradykinin in man have been less extensively studied. Fox et al. observed that intra-arterial or intravenous administration of bradykinin increased blood flow to the hand and forearm. These investigators also found that blood flow to the skin of the hand, forearm, face, and neck increased during the admin...
متن کاملIntracoronary and Epicardial Bradykinin
Background. Stimulation of left ventricular (LV) receptors with sympathetic afferents generally results in reflex sympathoexcitatory responses. Stimulation of LV receptors with vagal afferents results in reflex sympathoinhibitory responses. Vagal afferents are known to be preferentially distributed to the inferoposterior (IP) wall of the LV. We tested the hypothesis that there is also a prefere...
متن کاملVasodepressor role of endogenous bradykinin assessed by a bradykinin antagonist.
This study was designed to examine the contribution of bradykinin to the depressor effect of different antihypertensive drugs in two-kidney renovascular hypertensive rats, using a new specific antagonist of bradykinin. First, the inhibitory capacity of this peptide for exogenously injected bradykinin (75-200 ng) was tested. An inhibition of the vasodepressor action of bradykinin by over 50% was...
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ژورنال
عنوان ژورنال: Nature
سال: 1960
ISSN: 0028-0836,1476-4687
DOI: 10.1038/188999a0