Bovine papillomavirus transmission and chromosomal aberrations: an experimental model.

Human Genetics – Chromosomal Aberrations

Propranolol induced chromosomal aberrations in Chinese hamster ovary cell line

Propranolol (PL), a non-selective beta-blocker, is a cardiovascular drug widely used to treat hypertension. The present study was concerned with assessing the cytogenetic effects of this drug on Chinese hamster ovary (CHO) cell line. MTT assay was then carried out to determine the cytotoxicity index (IC50) of the drug. The IC50 value of PL was 0.43±0.02 mM. To investigate the clastogenic effect...

Chromosomal aberrations in iris melanomas.

BACKGROUND Uveal melanomas can develop in the choroid, ciliary body and iris. In choroidal and ciliary body melanomas, specific chromosomal changes correlate with metastatic disease. Iris melanomas have a better prognosis than choroidal melanomas, and it would be interesting to know if they share chromosomal changes. In addition, iris melanomas might harbour UV-induced mutations of tumour suppr...

Chromosomal aberrations, clastogens vs aneugens.

Current anticancer therapy may be one of the most important exogenous sources of exposure to genotoxic agents in US, Japan, and Europe, where approximately 40-55 percent of the population is diagnosed with cancer at a certain point in their life. This review focuses on recent efforts to integrate a novel biomarker, gamma-H2AX, into anticancer drug screening to classify the mode of action (MoA) ...

Chromosomal aberrations in Perinatal Asphyxia

This study was conducted to evaluate the level of chromosomal damage in perinatal asphyxia and correlate it with severity of asphyxia. Fourty term neonates with asphyxia and twenty term babies without asphyxia were included in this case control study. Blood samples were collected within 24 hours of birth for karyotyping and oxidative stress by serum malondealdehyde (MDA) estimation. The degree ...