Bovine Leukocyte Antigen Major Histocompatibility Complex Class II DRB3 * 2703 and DRB3 * 1501 Alleles Are Associated with Variation in Levels of Protection against Theileria parva Challenge following Immunization with the Sporozoite p67 Antigen
نویسندگان
چکیده
منابع مشابه
Association of the bovine leukocyte antigen major histocompatibility complex class II DRB3*4401 allele with host resistance to the Lone Star tick, Amblyomma americanum.
The MHC of cattle, known as the bovine leukocyte antigen (BoLA) complex, plays an integral role in disease and parasite susceptibility, and immune responsiveness of the host. While susceptibility to tick infestation in cattle is believed to be heritable, genes that may be responsible for the manifestation of this phenotype remain elusive. In an effort to analyze the role that genes within the B...
متن کاملAnalysis of variations, structures, and phylogenic characteristics of bovine leukocyte antigen DRB3 exon2
Bovine leukocyte antigen (BoLA) DRB3 is a highly polymorphic gene in major histocompatibility complex(MHC) class II that plays a central role in immune responses and production factors. As of yet, molecular andevolutionary characteristics of BoLA-DRB3.2* have not been as fully understood as human and mouse.Therefore, we attempted to analyze variability and phylogeny of BoLA-DRB3.2* and illustra...
متن کاملAssessment and optimization of Theileria parva sporozoite full-length p67 antigen expression in mammalian cells
Delivery of various forms of recombinant Theileria parva sporozoite antigen (p67) has been shown to elicit antibody responses in cattle capable of providing protection against East Coast fever, the clinical disease caused by T. parva. Previous formulations of full-length and shorter recombinant versions of p67 derived from bacteria, insect, and mammalian cell systems are expressed in non-native...
متن کاملBaculovirus surface display of Theileria parva p67 antigen preserves the conformation of sporozoite-neutralizing epitopes.
Theileria parva is an intracellular protozoan parasite that causes East Coast fever, a severe lymphoproliferative disease in cattle. Previous attempts to produce recombinant sporozoite surface antigen (p67) in bacterial or insect cells for vaccine purposes have not resulted in a correctly folded protein. Here, we report the expression of N- and C-terminal domains of p67 fused to the baculovirus...
متن کاملConservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles.
Immunity to Theileria parva infection in cattle is often parasite stock specific. The antigenic diversity which is expressed at the schizont stage of the parasite together with a wild reservoir of the organism in buffalo has complicated the development of effective disease control by immunization. We have previously shown that about 70% of cattle inoculated with recombinant forms of p67, a spor...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2004
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.72.5.2738-2741.2004