Bovine Herpesvirus 5 (BHV-5) Us9 Is Essential for BHV-5 Neuropathogenesis
نویسندگان
چکیده
منابع مشابه
Bovine herpesvirus 5 (BHV-5) Us9 is essential for BHV-5 neuropathogenesis.
Bovine herpesvirus 5 (BHV-5) is a neurovirulent alphaherpesvirus that causes fatal encephalitis in calves. In a rabbit model, the virus invades the central nervous system (CNS) anterogradely from the olfactory mucosa following intranasal infection. In addition to glycoproteins E and I (gE and gI, respectively), Us9 and its homologue in alphaherpesviruses are necessary for the viral anterograde ...
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Herpesvirus glycoprotein C (gC) is one of the major virus attachment proteins. Bovine herpesvirus type 1 (BHV-1) causes respiratory and genital diseases in cattle, whereas BHV-5 causes acute meningoencephalitis in calves. The gC gene sequence of these two viruses are substantially different. To determine the contribution of the BHV-5 glycoprotein gC (gC5) to the neuropathogenesis of BHV-5, we h...
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The alphaherpesvirus envelope protein Us9 is a type II viral membrane protein that is required for anterograde spread of bovine herpesvirus 5 (BHV-5) infection from the olfactory receptor neurons to the brain. In a rabbit seizure model, Us9-deleted BHV-5 failed to invade the central nervous system (CNS) following intranasal infection. However, when injected directly into the olfactory bulb, ret...
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Departamento de Medicina Veterinária Preventiva-DMVP, Microbiologia e Parasitologia/DMP, Departamento de Patologia da Universidade Federal de Santa Maria-UFSM. Santa Maria, RS, Brasil. Centro de Pesquisas Veterinárias Desidério Finamor (CPVDF), Eldorado do Sul, RS, Brasil and Departamento de Microbiologia. Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. Universidade do Esta...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2002
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.76.8.3839-3851.2002