Botulinum toxin B increases intrinsic muscle activity in organotypic spinal cord–skeletal muscle co-cultures
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چکیده
منابع مشابه
Intrinsic activity and positive feedback in motor circuits in organotypic spinal cord slice cultures.
In co-cultures of embryonic rat spinal cord slices and skeletal muscle, spinal motoneurons innervate muscle fibres and drive muscle contractions. However, multi-electrode array (MEA) recordings show that muscle contractions often appear in the absence of population activity in the spinal cord networks. Such uncorrelated muscle activity persists when the population bursts in the neuronal network...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2016
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2015.08.003