Both 5-HT<sub>1A</sub> and 5-HT<sub>1B</sub> receptor-mediated inhibition of glutamatergic transmission onto cholinergic neurons in basal forebrain
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چکیده
منابع مشابه
Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons.
Adenosine has been proposed as an endogenous homeostatic sleep factor that accumulates during waking and inhibits wake-active neurons to promote sleep. It has been specifically hypothesized that adenosine decreases wakefulness and promotes sleep recovery by directly inhibiting wake-active neurons of the basal forebrain (BF), particularly BF cholinergic neurons. We previously showed that adenosi...
متن کاملSomatostatin presynaptically inhibits both GABA and glutamate release onto rat basal forebrain cholinergic neurons.
A whole cell patch-clamp study was carried out in slices obtained from young rat brain to elucidate the roles of somatostatin in the modulation of synaptic transmission onto cholinergic neurons in the basal forebrain (BF), a region that contains cholinergic and GABAergic corticopetal neurons and somatostatin (SS)-containing local circuit neurons. Cholinergic neurons within the BF were identifie...
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2 Intrinsic Voltage Dynamics Govern the Diversity of Spontaneous Firing 3 Profiles in Basal Forebrain Non-cholinergic Neurons 4 5 6 Saak V. Ovsepian, Oliver J. Dolly and Laszlo Zaborszky 7 8 (1) Centre for Molecular and Behavioral Neuroscience, Rutgers, The State University of 9 New Jersey, 197 University Avenue, Newark, NJ 07102, USA; (2) International Centre 10 for Neurotherapeutics, Research...
متن کاملCharacterization of age-related changes in synaptic transmission onto F344 rat basal forebrain cholinergic neurons using a reduced synaptic preparation.
Basal forebrain (BF) cholinergic neurons participate in a number of cognitive processes that become impaired during aging. We previously found that age-related enhancement of Ca(2+) buffering in rat cholinergic BF neurons was associated with impaired performance in the water maze spatial learning task (Murchison D, McDermott AN, Lasarge CL, Peebles KA, Bizon JL, and Griffith WH. J Neurophysiol ...
متن کاملCholinergic neurons excite cortically projecting basal forebrain GABAergic neurons.
The basal forebrain (BF) plays an important role in the control of cortical activation and attention. Understanding the modulation of BF neuronal activity is a prerequisite to treat disorders of cortical activation involving BF dysfunction, such as Alzheimer's disease. Here we reveal the interaction between cholinergic neurons and cortically projecting BF GABAergic neurons using immunohistochem...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2018
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.wcp2018.0_po1-1-120