Boronic acid inhibitors of porcine pancreatic lipase.
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چکیده
منابع مشابه
Polyphenolic Compounds as Pancreatic Lipase Inhibitors.
Obesity and its associated diseases such as diabetes mellitus and coronary heart diseases are a major challenge for our society. An important target for the treatment of obesity includes the development of inhibitors of nutrient digestion and absorption. Inhibition of pancreatic lipase and the associated reduction of lipid absorption is an attractive approach for the discovery of potent agents....
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Two trypsin inhibitors of the Kazal type have been isolated from porcine pancreatic juice. They have been prepared in 65% yield by gel titration on Sephadex G-75 at pH 8.1 in the presence of lo-*M diisopropyl phosphofluoridate, tiltration through diethylaminoethyl cellulose at pH 9, and equilibrium chromatography on sulfoethyl Sephadex at pH 5.4. The major component, Porcine Inhibitor I, has a ...
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The proteasome degrades numerous regulatory proteins that are critical for tumor growth. Thus, proteasome inhibitors are promising antitumor agents. New proteasome inhibitors, such as tyropeptins and tyropeptin-boronic acid derivatives, have a potent inhibitory activity. Here we report the antitumor effects of two new tyropeptin-boronic acid derivatives, AS-06 and AS-29. AS-06 and AS-29 signifi...
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3 Running Title: Boronic Acid Inhibitors and SHV 4 5 Jodi M. Thomson, Fabio Prati, Christopher R. Bethel, and Robert A. Bonomo* 6 7 8 Department of Pharmacology, Case Western Reserve University School of Medicine, 9 Cleveland, Ohio; Department of Chemistry, University of Modena, Modena, Italy; 10 Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 11 12 13 14...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1980
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)70749-2