منابع مشابه
Borinic acid catalysed peptide synthesis.
The catalytic synthesis of peptides is a major challenge in the modern organic chemistry hindered by the well-established use of stoichiometric coupling reagents. Herein, we describe for the first time that borinic acid is able to catalyse this reaction under mild conditions with an improved activity compared to our recently developed thiophene-based boronic acid. This catalyst is particularly ...
متن کاملMesityl(2,4,6-trimethoxyphenyl)borinic acid
In the title mol-ecule, C(18)H(23)BO(4), the dihedral angle between the least-squares planes of the aromatic rings is 84.88 (3)°. The B atom deviates by 0.202 (1) Å from the least-squares plane of the mesityl ring. All of the meth-oxy groups are approximately coplanar with the 2,4,6-trimeth-oxy-phenyl ring, whereas the BOH group is twisted with respect to it by 19.5°. The borinic OH group is en...
متن کاملImproving the carboxyamidomethyl ester for subtilisin A-catalysed peptide synthesis.
A series of novel glycine esters was evaluated for efficiency in subtilisin A-CLEA-catalysed peptide synthesis. The reactivity of the easily accessible carboxyamidomethyl (Cam) ester was further enhanced by elongating it with an amino acid residue, thereby creating more recognition space for subtilisin A.
متن کاملSynthesis and supramolecular assembly of the bifunctional borinic acid [1,2-fcB(OH)]2.
Treatment of the chloro-substituted diboradiferrocene derivative 1 with Me(3)SiOMe and subsequent hydrolysis resulted in formation of the novel organometallic bis(borinic acid) derivative 3. The assembly of 3 into supramolecular structures via hydrogen bonding and reversible covalent boron-oxygen bond formation was explored. Upon crystallization from acetone or THF one-dimensional chains form i...
متن کاملGold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles.
Amino acid-derived propargylic amides are cyclised in a one-pot, Au(III)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2015
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c5cc06177f