Boosting the antimicrobial performance based on new fused spirothiazolidine framework analogs

نویسندگان

چکیده

Abstract New spiro[cyclohexane-1,2'-thiazolo[4,5- b ]pyridine derivatives ( 3 – 23 ) were investigated. Then there is in vitro antimicrobial potency against possible organisms Staphylococcus aurous ATCC-47,077, Bacillus cereus ATCC-12228, Escherichia coli ATCC-25922, Salmonella typhi ATCC-15566, and Candida albicans ATCC-10231 tested utilizing commercially available antibiotics ampicillin as a reference drug. A preliminary test represented that derivatives: (Aldoses) 3'-(4-fluorophenyl)-5'-(methyleneamino)-7'-( p -tolyl)- 3'H -spiro[cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile 16–19 (Acetyl aldoses) -spiro [cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile 20–23 exhibited higher antifungal, antibacterial performance with minimum inhibitory concentrations values of (39–67 µg/ml) toward all pathogenic strains compared to common drug ampicillin.

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ژورنال

عنوان ژورنال: Journal of The Iranian Chemical Society

سال: 2022

ISSN: ['1735-2428', '1735-207X']

DOI: https://doi.org/10.1007/s13738-022-02595-8