Bone-Resorbing Osteoclasts Contain Gap-Junctional Connexin-43
نویسندگان
چکیده
منابع مشابه
Connexin-mimetic peptide Gap 27 decreases osteoclastic activity
BACKGROUND Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts contain gap-junctional protein connexin-43 and that a commonly used gap-junctional inhibitor, heptanol, can inhibit osteoclastic bone resorption. Since heptanol may also have some unspecific effect unrelated to gap-junctional inhibiti...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2010
ISSN: 0884-0431
DOI: 10.1359/jbmr.2000.15.5.919