Bone Marrow Transplantation and Graft-Versus-Host Reaction.
نویسندگان
چکیده
منابع مشابه
Bone marrow transplantation and graft-versus-host reaction.
Gribben JG, Freedman AS, Neuberg D, et al. Immunologic purging of marrowassessed by PCRbefore autologous bone marrowtransplantation for B-cell lymphoma. N Engl J Med 325: 1525, 1991. HamonMD, Prentice HG, Gottlieb DJ, et al. Immunotherapy with interleukin 2 after ABMTin AML.Bone Marrow Transplant ll: 399, 1993. Yanai N, Sekine C, Yagita H, Obinata M, Roles for integrin vary late activation anti...
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Graft versus host disease is a major barrier in allogeneic bone marrow transplantation. The associated morbidity and mortality need to be understood and prevented if possible, as the potential indications for bone marrow transplantation continue to broaden. Areas of investigation include the cellular effector arm as well as the cytokines associated with the expression of the disease.
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We recently showed that IL-11 prevents lethal graft-versus-host disease (GVHD) in a murine bone marrow transplantation (BMT) model of GVHD directed against MHC and minor antigens. In this study, we have investigated whether IL-11 can maintain a graft-versus-leukemia (GVL) effect. Lethally irradiated B6D2F1 mice were transplanted with either T cell-depleted (TCD) bone marrow (BM) alone or with B...
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Allogeneic bone marrow transplantation is a curative treatment for leukemia and lymphoma, but graft-vs-host disease (GVHD) remains a major complication. Using a GVHD protective nonmyeloablative conditioning regimen of total lymphoid irradiation and antithymocyte serum (TLI/ATS) in mice that has been recently adapted to clinical studies, we show that regulatory host NKT cells prevent the expansi...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 1996
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.35.73