Bone marrow mononuclear cells and acute myocardial infarction
نویسندگان
چکیده
منابع مشابه
Bone Marrow Mononuclear Cell Therapy for Acute Myocardial Infarction
To understand the role of bone marrow mononuclear cells in the treatment of acute myocardial infarction, this overview offers a retrospective examination of strengths and limitations of 3 contemporaneous trials with attention to critical design features and provides an analysis of the combined data set and implications for future directions in cell therapy for acute myocardial infarction. (Circ...
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In 2002, Strauer et al. reported the results of the first phase I study testing the safety of intracoronary (IC) administration of autologous bone marrow mononuclear stem cells (BMMSCs) for acute myocardial infarction (AMI). Since then, we have seen a series of trials using mixed cell types with heterogeneous designs in terms of both the number and the timing of BMMSCs administration that have ...
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BACKGROUND Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction. METHODS In a multicenter trial, we randomly assigned 204 patients with acute myocardial infarction to receive an intracoronary infusion of progenitor cells derived from bone marrow (BMC) or placebo medium into the infarct...
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When news broke in 2001 that bone marrow– derived stem cells (BMCs) regenerate cardiac myocytes after myocardial infarction (MI), the prospects of regenerative therapy suddenly dawned on the horizon of cardiovascular medicine. Along with reports about differentiation of BMCs into neurons, hepatocytes, and muscle,1–4 BMCs delivered to the heart were shown to transdifferentiate into cardiac myocy...
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A decade ago, 3 potentially groundbreaking trials were published that ushered in a new era of cardiovascular regenerative medicine. Using autologous bone marrow mononuclear cells (BMCs) in patients with acute STsegment–elevation myocardial infarction (STEMI), the trials were notable for their clear signal of safety, but discordant in their findings of benefit. Unfortunately, the 1-year results ...
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ژورنال
عنوان ژورنال: Stem Cell Research & Therapy
سال: 2012
ISSN: 1757-6512
DOI: 10.1186/scrt93