Bone development and remodeling in metabolic disorders
نویسندگان
چکیده
منابع مشابه
Update in osteoporosis and metabolic bone disorders.
Considerable progress has been made in the development and testing of agents to treat osteoporosis. Most impressive are reports on new antiresorptive agents--both bisphosphonates (ibandronate and zoledronic acid) and monoclonal antibodies (MAbs) (denosumab) directed against receptor activator of nuclear factor kappaB-ligand, a key molecule in the control of commitment and activation of osteocla...
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In clinical practice, low bone mineral densi ty (BMD) and, therefore, scarcity of bone mineral is identified and quantified by dual energy X-ray absorptio-metry (DXA) (1). However, BMD predicts only 66Ê74% of variance of the bone strength (2), and many individuals with normal areal BMD suffer fractures (3). It is well recognized that other aspects of bone composition and structure may contribut...
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ژورنال
عنوان ژورنال: Journal of Inherited Metabolic Disease
سال: 2019
ISSN: 0141-8955,1573-2665
DOI: 10.1002/jimd.12097