Bone biomarkers of ovariectomised rats after leptin therapy
نویسندگان
چکیده
منابع مشابه
The Effect of Peripheral Injection of Leptin on Biomarkers of Aging in Calorie Restricted Rats
Background and Objectives: Calorie restriction (CR) is one of the proven methods of extending lifespan and slowing aging. Leptin is a nutritionally regulated adipokine that has been proposed as a possible key signal in the adaptive responses relevant to CR. Under CR, plasma leptin levels decrease, thus it was hypothesized that leptin administration may counteract CR-induced weight loss. Therefo...
متن کاملFish-bone peptide increases calcium solubility and bioavailability in ovariectomised rats.
Fish-bone peptides (FBP) with a high affinity to Ca were isolated using hydroxyapatite affinity chromatography, and FBP II with a high ratio of phosphopeptide was fractionated in the range of molecular weight 5.0-1.0 kDa by ultramembrane filtration. In vitro study elucidated that FBP II could inhibit the formation of insoluble Ca salts in neutral pH. In vivo effects of FBP II on Ca bioavailabil...
متن کاملBone micro-architectural analysis of mandible and tibia in ovariectomised rats
OBJECTIVES This study aims to evaluate if micro-CT can work as a method for the 3D assessment and analysis of cancellous bone by comparing micro-CT with undecalcified histological sections in OVX rats. METHODS The mandible and tibia of sham, ovariectomised (OVX) and zoledronate-injected ovariectomised (OVX-ZOL) rats were assessed morphometrically. Specimens were scanned by micro-CT. Undecalci...
متن کاملMulti-Elemental Profiling of Tibial and Maxillary Trabecular Bone in Ovariectomised Rats
Atomic minerals are the smallest components of bone and the content of Ca, being the most abundant mineral in bone, correlates strongly with the risk of osteoporosis. Postmenopausal women have a far greater risk of suffering from OP due to low Ca concentrations in their bones and this is associated with low bone mass and higher bone fracture rates. However, bone strength is determined not only ...
متن کاملEffect of Erythropoietin on Serum Brain-derived Biomarkers after Carbon Monoxide Poisoning in Rats
Objective(s) Erythropoietin has been shown to exert neuroprotective effects in a variety of CNS injury models. Elevation of serum S100β, as a glial damage marker and myelin basic protein (MBP) has been reported to occur in acute carbon monoxide (CO) poisoning. The aim of this study was to evaluate the effect of erythropoietin (EPO) on serum S100β and MBP levels after CO poisoning in rats. Mat...
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ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2013
ISSN: 1336-0345
DOI: 10.4149/bll_2013_064