Blunted nutrient-response pathways in adipose tissue following high fat meals in men with metabolic syndrome: A randomized postprandial transcriptomic study

BackgroundExcessive adipose tissue is central to disease burden posed by the Metabolic Syndrome (MetS). Whilst much known of altered transcriptomic regulation under fasting conditions, little responses high-fat meals.MethodsNineteen middle-aged males (mean ± SD 52.0 4.6 years), consumed two isocaloric high-fat, predominately dairy-based or soy-based, breakfast meals. Abdominal subcutaneous biopsies were collected after overnight fast (0 h) and 4 h following each meal. Global gene expression profiling was performed microarray (Illumina Human WG-6 v3).ResultsIn fasted state, 13 genes differently expressed between control MetS (?1.2 fold-difference, p < 0.05). In response meals, participants had widespread increases in related cellular nutrient fold-change, 0.05; 2444 & 2367 genes; dairy soy, respectively). There blunted group 332 336 respectively).ConclusionsIn with MetS, a suppression responsive suggests an inflexibility responsiveness both Excessive Nineteen v3).