Blocking TLR2 Activity Attenuates Pulmonary Metastases of Tumor

Blocking TLR2 Activity Attenuates Pulmonary Metastases of Tumor

BACKGROUND Metastasis is the most pivotal cause of mortality in cancer patients. Immune tolerance plays a crucial role in tumor progression and metastasis. METHODS AND FINDINGS In this study, we investigated the potential roles and mechanisms of TLR2 signaling on tumor metastasis in a mouse model of intravenously injected B16 melanoma cells. Multiple subtypes of TLRs were expressed on B16 cel...

Suppressive Immune Microenvironment Inflammation and Fibrosis by Reversion of Targeting TLR2 Attenuates Pulmonary

Implantation Vessels, and Pulmonary Metastases following Tumor Quantitative Relationships of Intravascular Tumor Cells, Tumor

SUMMARY An experimental model has been developed to quantify some of the major processes initiated by tumor transplanta tion and culminating in pulmonary métastases. The T241 fibrosarcoma, chosen because of its high hematogenous metastatic propensity and reproducible biological behavior, is transplanted into the femoral region of the C57BL mouse. Experiments are performed at specified times af...

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.

An experimental model has been developed to quantify some of the major processes initiated by tumor transplanta tion and culminating in pulmonary métastases.The T241 fibrosarcoma, chosen because of its high hematogenous metastatic propensity and reproducible biological behavior, is transplanted into the femoral region of the C57BL mouse. Experiments are performed at specified times after trans...

Esophageal gastrointestinal stromal tumor with pulmonary and bone metastases.

Gastrointestinal stromal tumors (GISTs) are rare neoplasms of the gastrointestinal tract. One to three percent of GISTs occur in the esophagus. GISTs have a great potential for diffuse intra- abdominal spread and liver metastasis, which are the two most common modes of dissemination. Metastases to other sites, especially the bones and lung, are relatively rare. Never has an esophageal GIST been...