Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis
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چکیده
منابع مشابه
Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9.
Patched (Ptc), the main receptor for Sonic Hedgehog, is a tumor suppressor. Ptc has been shown to be a dependence receptor, and as such triggers apoptosis in the absence of its ligand. This apoptosis induction occurs through the recruitment by the Ptc intracellular domain of a caspase-activating complex, which includes the adaptor proteins DRAL and TUCAN, and the apical caspase-9. We show here ...
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متن کاملInhibition of Tumor Promotion through Blocking Signal Transduction
67 INTRODUCTION 67 MOLECULAR MECHANISM OF TUMOR PROMOTION BY TPA 68 TPA activates phosphorylation of serine/threonine 68 TPA induces oxidative stress 69 TPA activates early response genes 71 ANTI-CARCINOGENESIS OF SEVERAL NATURAL POLYPHENOLIC COMPOUNDS 72 CURCUMIN INHIBITS TUMOR PROMOTION THROUGH BLOCKING SIGNAL TRANSDUCTION 73 DISCUSSION 74 ACKNOWLEDGEMENTS , 74 REFERENCES 74 CHINESE ABSTRACT 81
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2020
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-19-1340