Blocked Gap Junctional Coupling Increases Glutamate-Induced Neurotoxicity in Neuron-Astrocyte Co-Cultures
نویسندگان
چکیده
منابع مشابه
Blocked gap junctional coupling increases glutamate-induced neurotoxicity in neuron-astrocyte co-cultures.
Gap junctional communication is likely one means by which neurons can endure glutamate cytotoxicity associated with CNS insults (i.e. ischemia). To examine this neuroprotective role of gap junctions, we employed gap junctional blockers to neuronal and astrocytic co-cultures during exposure to a high concentration of extracellular glutamate. Co-cultures were treated with the blocking agents carb...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2002
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/61.2.132