Blockade of ActRIIB Signaling Triggers Muscle Fatigability and Metabolic Myopathy
نویسندگان
چکیده
منابع مشابه
Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy.
Myostatin regulates skeletal muscle size via the activin receptor IIB (ActRIIB). However, its effect on muscle energy metabolism and energy-dependent muscle function remains largely unexplored. This question needs to be solved urgently since various therapies for neuromuscular diseases based on blockade of ActRIIB signaling are being developed. Here, we show in mice, that 4-month pharmacologica...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2014
ISSN: 1525-0016
DOI: 10.1038/mt.2014.90