Bleomycin induced hyperpigmentation of skin

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Bleomycin-induced flagellate hyperpigmentation.

Bleomycin is a chemotherapeutic agent used in the treatment of different tumours. It has several side effects, including flagellate hyperpigmentation, which is a unique and a well-documented side effect of bleomycin therapy. We report a case of a 23-year-old woman with a personal history of ovarian dysgerminoma, who developed flagellate hyperpigmentation on trunk after bleomycin therapy.

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Flagellate hyperpigmentation from bleomycin.

Sir, Mucocutaneous side effects associated with bleomycin are stomatitis, ulcers, scaly erythematous and bullous lesions, sclerosis, nail changes, digital gangrene and pigmentary alterations. Hyperpigmentation occurring mainly on the pressure areas of the skin as well as in areas of scratch marks is seen in approximately 30% of patients. Flagellate hyperpigmentation is very characteristic of bl...

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ژورنال

عنوان ژورنال: Hematology, Transfusion and Cell Therapy

سال: 2018

ISSN: 2531-1379

DOI: 10.1016/j.bjhh.2017.08.005