Black tea extract, thearubigin fraction, counteract the effects of botulinum neurotoxins in mice
نویسندگان
چکیده
منابع مشابه
Public Health Burden of Botulinum Neurotoxicity: A Research Perspective to Evaluate the Antitoxin Efficacy of Thearubigin Extract of Black Tea
Botulinum toxin (BoNT), being the most poisonous substance poses a great threat to global public health as a deadly bio-weapon. BoNT/A, BoNT/B and BoNT/E serotype toxicity cause flaccid paralysis in human by blocking neurotransmitter activity. Thearubigin, a black tea extract is found to be effective in neutralizing BoNT when experimented with animal models. This hypothesis opens a new frontier...
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This review explores current evidence to demonstrate that botulinum neurotoxins (BoNTs) exert antipruritic effects. Both experimental and clinical conditions in which botulinum neurotoxins have been applied for pruritus relief will be presented and significant findings will be highlighted. Potential mechanisms underlying antipruritic effects will also be discussed and ongoing challenges and unm...
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Introduction: In this study, the effects of black tea extract of Iranian tea plant (Camellia sinensis var sinensis) and its polyphenolic pigment thearubigins were investigated on mice intestinal transit time. Method: Thearubigins were isolated by liquid-liquid fraction method. The effects of black tea extract and isolated thearubigins on intestinal propulsion were measured by charcoal propulsio...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2001
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0703883