BK Virus Nephropathy Revisited

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[BK-virus-associated Nephropathy].

The infection by the BK Polyomavirus (BKV) is an emerging problem in kidney transplants that contributes to a chronic loss of kidney grafts, and in which immunosuppression plays a decisive role. Understanding its risk factors and strictly monitoring urine and serological markers of the infection could mitigate the undesirable effects of this disease. In this review, we investigate the clinical ...

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BK virus nephropathy is not always alone.

INTRODUCTION BK virus associated allograft nephropathy (BKVAN) is an important cause of allograft lost that often occurs in the first year of transplantation. The state of over immunosuppression also predispose these patients to various opportunistic viral infection Objectives: This research aimed to study the renal transplanted patients for BK viremia and BKVAN. PATIENTS AND METHODS This obs...

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Intravenous immunoglobulin in BK virus nephropathy

The incidence of post transplant viral infections has increased with the use of more potent immunosuppressive regimens. Consequently, BK virus nephropathy (BKVN) has arisen as a significant cause of graft dysfunction and loss. Reduction of immunosuppression is the first line management of post-transplant viral infections. Other therapies such as intravenous immunoglobulin (IVIg), cidofovir, lef...

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BK virus nephropathy and kidney transplantation.

Nephropathy from BK virus (BKV) infection is an evolving challenge in kidney transplant recipients. It is the consequence of modern potent immunosuppression aimed at reducing acute rejection and improving allograft survival. Untreated BKV infections lead to kidney allograft dysfunction or loss. Decreased immunosuppression is the principle treatment but predisposes to acute and chronic rejection...

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BK virus nephropathy and other polyoma virus infections.

Polyomaviruses are mammalian (and a few avian) viruses, which appear to have coevolved with their hosts, leading to high prevalence, low morbidity, latent infections for the most part. The viruses generally have a restricted host range; 5 polyomaviruses are known to naturally infect humans (Table 1). Among them, BK virus is the most commonly encountered clinically, causing nephropathy, hemorrha...

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ژورنال

عنوان ژورنال: American Journal of Transplantation

سال: 2017

ISSN: 1600-6135

DOI: 10.1111/ajt.14358