Biting the Hand

Proteasome assembly: Biting the hand…

Proteasome assembly is regulated to ensure the enzyme is inactive until its active sites are compartmentalized within an interior aqueous chamber. In yeast, this depends on a dedicated chaperone that is trapped within the nascent proteasome, and degraded on maturation of the proteolytic subunits.

Blood donor deferrals: biting the hand that feeds us!

I n this issue of TRANSFUSION, the article by Zou and colleagues details trends in donor deferral and retention using the American Red Cross database. The power of the study is the enormous experience culled from almost half the nation’s blood supply. Prominent among the observations are the increasing deferrals for failing to achieve minimum hemoglobin (Hb)/ hematocrit (Hct) criteria and for d...

Outsourcing suppliers as downstream competitors: Biting the hand that feeds

In this paper, we highlight an aspect of supplier opportunism in the outsourcing paradox that has largely been ignored by extant research – the supplier as a direct competitor of the buyer firm. In light of this paradox, we offer a game-theoretic framework in which we identify conditions under which firms could alleviate or mitigate this outsourcing problem. Our results show that apart from tra...

Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function.

The 26S proteasome of eukaryotic cells mediates ubiquitin-dependent as well as ubiquitin-independent degradation of proteins in many regulatory processes as well as in protein quality control. The proteasome itself is a dynamic complex with varying compositions and interaction partners. Studies in Saccharomyces cerevisiae have revealed that expression of proteasome subunit genes is coordinately...

Biting the Hand that Starves You: Inspiring Resistance to Anorexia/Bulimia