Bisphosphonates-what’s new?

Bisphosphonates are chemical-related to pyrophosphate. The oxygen atom in pyrophosphate is substituted by a carbon these compounds, resulting P-C-P bond. They potent antiresorptive medicines because they have strong inhibitory effect on osteoclasts. It lowers fracture risk reducing bone turnover, increasing mineral density, and decreasing the lumbar spine hip. strongly attracted surfaces, where accumulate, primarily at remodeling sites. rarely associated with systemic side effects due their selectivity action. Irritation of upper gastrointestinal tract most common effect. A third-generation bisphosphonate, zoledronate, currently approved treat postmenopausal-induced osteoporosis. This review mainly focuses mechanism action, therapeutic uses, its adverse effects.