منابع مشابه
Bisphosphonates in breast cancer: antitumor effects.
Bone metastases add to the burden of breast cancer, with patients experiencing severe bone pain, pathologic fractures, spinal cord compression, and hypercalcemia of malignancy. Nitrogen-containing bisphosphonates have become the standard treatment for skeletal-related events and bone pain, as well as for bone loss associated with chemotherapy and aromatase inhibitors. Emerging preclinical and c...
متن کاملBisphosphonates in the Management of Breast Cancer.
BACKGROUND: Bone is the most frequent site of metastasis in patients with breast cancer. Bone metastasis, particularly osteolytic bone destruction, is usually associated with significant morbidity and deterioration of quality of life. Bisphosphonates are specific inhibitors of osteoclast activity used in the treatment of hypercalcemia of malignancy and osteolytic bone disease. METHODS: We revie...
متن کاملBisphosphonates in breast cancer: a triple winner?
The medical management of a patient with cancer involves three essential components: prevention of cancer-related morbidity, management of the side effects of anticancer therapy, and most importantly, control of tumor growth. Bisphosphonates are effective on all three of these fronts, as highlighted in the review by Drs. Blanchette and Pritchard.[1] However, despite years of research on the rol...
متن کاملBisphosphonates, bone, and breast cancer recurrence
Bisphosphonates reduce bone turnover by inhibiting osteoclast maturation and function, and are important in the prevention of age-related osteoporosis and bone fracture, in the prevention of complications of bone metastases, and in the prevention of osteopenia and osteoporosis resulting from adjuvant aromatase inhibitor therapy of breast cancer. Over 125 years ago, in The Lancet, Paget hypothes...
متن کاملBisphosphonates and breast cancer incidence and recurrence.
Bisphosphonates are commonly used in patients with breast cancer to reduce skeletal-related events in metastatic disease and to mitigate bone loss associated with adjuvant therapy. Preclinical studies have shown that bisphosphonates may directly inhibit breast cancer cell proliferation and metastasis. Clinical trials evaluating the oral bisphosphonate clodronate as a component of adjuvant thera...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2005
ISSN: 0923-7534
DOI: 10.1093/annonc/mdi162