Bisphenol A as degradation product of monomers used in resin-based dental materials

There is still much debate about the release of bisphenol-A (BPA) from dental materials. Therefore, this study aimed to quantify BPA present as an impurity in both BPA-based and non-BPA-based monomers evaluate whether these may degrade upon salivary, bacterial, chemical challenges. was determined three different amounts (1, 2, 3 ?mol) each monomer (TEGDMA, UDMA, mUDMA, BisGMA, BisEMA-3, -6, -10, -30, BisPMA, EBPADMA urethane, BADGE, BisDMA). Next, (3 were immersed whole human pooled saliva collected adults, Streptococcus mutans (2 × 107 CFU/mL), acidic (0.1 M HCl), alkaline NaOH), control media. The amount quantified using a specific highly sensitive UPLC–MS/MS method including derivatization by pyridine-3-sulfonyl chloride. BisGMA BisEMA-3 contained trace (0.0006% 0.0025%, respectively) impurities their synthesis process. concentrations increased when BisEMA-6, BisEMA-10, BisPMA BADGE exposed S. mutans, indicating degradation small into BPA. In addition, degraded under conditions. conversion rate ranged between 0.0003% 0.0025%. Impurities account for resin-based Even though detected due small, manufacturers materials can reduce content only highest purity. Considering overall current trend towards BPA-free materials, it be recommendable investigate non-BPA based used