BiP Binding Keeps ATF6 at Bay

Nicotine Keeps Leaf-Loving Herbivores at Bay

Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response.

Endoplasmic reticulum (ER) stress-induced activation of ATF6, an ER membrane-bound transcription factor, requires a dissociation step from its inhibitory regulator, BiP. It has been generally postulated that dissociation of the BiP-ATF6 complex is a result of the competitive binding of misfolded proteins generated during ER stress. Here we present evidence against this model and for an active r...

Statin a day keeps cancer at bay. [World J Clin Oncol. 2013] - PubMed - NCBI

Abstract In addition to cholesterol reduction, statins, currently the most commonly prescribed drug in the world, have been shown to have anti-neoplastic and immunomodulatory effects. Several observational studies and meta-analyses have shown reduction in risk of multiple cancers. More recently there has been an increasing interest in the potential role of statins as adjuvant therapy after canc...

Cancer and Inflammation: An Aspirin a Day Keeps the Cancer at Bay

Live imaging of the interactions between oncogene-transformed cells and leukocytes in zebrafish reveals that PGE(2) promotes the survival and proliferation of cancer cells. Non-steroid anti-inflammatory drugs, like aspirin, are the effective inhibitors of PGE(2) production and could be used with other anti-tumor agents in the treatment of cancer.

What Keeps You Awake at Night?

Session overview What’s happening? What does the future hold? What keeps you awake at night? The times they are a-changin’. So sang Bob Dylan back in 1963. And those words still resonate today – whether in politics and society, or fundraising and the nonprofit sector. So what do advanced executives do? What cage-rattling questions (CRQs) do leaders ask? How do leaders use conversation as a core...