Biotransformation of oral contraceptive ethynodiol diacetate with microbial and plant cell cultures

Biotransformation of oral contraceptive ethynodiol diacetate with microbial and plant cell cultures

UNLABELLED BACKGROUND Biotransformation by using microbial and plant cell cultures has been applied effectively for the production of fine chemicals on large scale. Inspired by the wealth of literature available on the biotransformation of steroids, we decided to investigate the biotransformation of ethynodiol diacetate (1) by using plant and microbial cultures. RESULTS The biotransformati...

Progesterone biotransformation by plant cell suspension cultures.

Progesterone was converted to 5alpha-pregnane-3alpha-ol-20-one, delta4-pregnene-20alpha-ol-3-one, delta4-pregnene-14alpha-ol-3,20-dione, delta4-pregnene-7beta,14alpha-diol-3,20-dione, and delta4-pregnene-6beta,11alpha-diol-3,20-dione by cell cultures of Lycopersicon esculentum. Cell cultures of Capsicum frutescens (green) metabolized progesterone to delta4-pregnene-20alpha-ol-3-one in very high...

Biotransformation of Vincamine using Microbial cultures

Microbial transformation is a complementary tool in the investigation of drug metabolism. In the present investigation, biotransformation of vincamine was studied using microbial cultures. Bacterial, fungal, and yeast cultures were employed to elucidate the metabolism of vincamine. The results indicate that a number of microorganisms metabolized vincamine to various levels to yield three major ...

Low-dosage oral ethynodiol diacetate tablets for long-term contraception in Indian women.

Biotransformation of Aromatic Aldehydes by Cell Cultures of Peganum harmala L. and Silybum marianum (L.) Gaertn.

Many aldehydes are important components of natural flavours. They are used in food, cosmetic, and biomedical industries in large amounts. Plant cells or microorganisms carry out their production by biotransformation, which is one of the biotechnological methods that allow them to be defined as 'natural'. Cell cultures of Silybum marianum and Peganum harmala have been studied with a view to in...