منابع مشابه
Natural products as leads in schistosome drug discovery.
Schistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human lives every year. Praziquantel (PZQ), the only drug recommended by the World Health Organization for the treatment and control of human schistosomiasis, is now facing the threat of drug resistance, indicating the urgent need for new effective compounds to treat this disease. Therefore, globally, there is ...
متن کاملNatural products: a continuing source of novel drug leads.
BACKGROUND Nature has been a source of medicinal products for millennia, with many useful drugs developed from plant sources. Following discovery of the penicillins, drug discovery from microbial sources occurred and diving techniques in the 1970s opened the seas. Combinatorial chemistry (late 1980s), shifted the focus of drug discovery efforts from Nature to the laboratory bench. SCOPE OF RE...
متن کاملSpirotetronate Polyketides as Leads in Drug Discovery
The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These microbial metabolites are structurally distinguished by the presence of a spirotetronate motif embedded within a macrocyclic core. Glycosylation at the periphery of this core contributes to the structural compl...
متن کاملGrifola gargal and G. sordulenta, Two Wild Edible Mushrooms with Perspectives as Biotech Products
Grifola gargal Singer and Grifola sordulenta Mont. (Singer) are two edible and medicinal mushroom species which occur in the AndinoPatagonian forests of Argentina and Chile. These woods that mainly consist of Nothofagus spp. are under increasing pressure with the consequent need of finding alternative sources for these mushrooms rather than gathering them. The main interest in these species is ...
متن کاملPlant-derived natural products as leads to anti-cancer drugs
Article Type: Review There are many difficulties and deficiencies in chemotherapeutic drugs especially drug resistances that appear in cancer chemotherapy. In spite of the fact that chemotherapeutic drugs are very effective, severe side effects limit the use of these drugs. People have to pay more attention to natural sources of cancer drugs to increase the anti-cancer agents present in the dru...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1995
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0795-649