Biotech 86: Protease and Anti–Protease Engineering
نویسندگان
چکیده
منابع مشابه
Protease and antiprotease levels in blood of arthritic rats.
Protease, antiprotease, and acid phosphatase blood levels of adjuvant arthritic rats were determined. The protease levels appear to vary inversely with the antiprotease levels. Changes in the protease levels correspond closely to changes in the acid phosphatase levels. Thus it is likely that the lysosomes contribute to the proteases present in the blood. Administered cortisol appears to raise b...
متن کاملProtease-Antiprotease Imbalance in Inflammatory Diseases in the Lung
We are very interested in the extensive research by Vernooy et al,1 who addressed the importance of matrix metalloproteases (MMPs) in the pathogenesis and/or the development of COPD. It is likely to be important to evaluate the activity of the proteases rather than the expression of MMPs. Protease/antiprotease imbalance has also been postulated to be important in the pathogenesis of COPD. Howev...
متن کاملProtease-antiprotease imbalance in inflammatory diseases in the lung.
We are very interested in the extensive research by Vernooy et al,1 who addressed the importance of matrix metalloproteases (MMPs) in the pathogenesis and/or the development of COPD. It is likely to be important to evaluate the activity of the proteases rather than the expression of MMPs. Protease/antiprotease imbalance has also been postulated to be important in the pathogenesis of COPD. Howev...
متن کاملThe origins of a concept: the protease-antiprotease imbalance hypothesis.
O ne of the more intense areas of research in lung disease in the past 40 years has been the investigation of mechanisms of lung parenchymal destruction by in vivo enzymatic proteolytic enzymes causing pulmonary emphysema and COPD. How this direction of research evolved is worth recounting because it illustrates how quite different experimental approaches done in different parts of the world at...
متن کاملRespiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants.
The respiratory epithelium functions as a central orchestrator to initiate and organize responses to inhaled stimuli. Proteases and antiproteases are secreted from the respiratory epithelium and are involved in respiratory homeostasis. Modifications to the protease/antiprotease balance can lead to the development of lung diseases such as emphysema or chronic obstructive pulmonary disease. Furth...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1986
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0886-698