Biosynthetic Mechanism of the Bioactive Sulfated Glycosaminoglycans
نویسندگان
چکیده
منابع مشابه
Human genetic disorders caused by mutations in genes encoding biosynthetic enzymes for sulfated glycosaminoglycans.
A number of genetic disorders are caused by mutations in the genes encoding glycosyltransferases and sulfotransferases, enzymes responsible for the synthesis of sulfated glycosaminoglycan (GAG) side chains of proteoglycans, including chondroitin sulfate, dermatan sulfate, and heparan sulfate. The phenotypes of these genetic disorders reflect disturbances in crucial biological functions of GAGs ...
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The sulfated glycosaminoglycans, such as keratan sulfate and chitin sulfate having 3-hydroxy free N-acetyl-beta-D-glucosaminyl residues as constituents, reacted with wheat germ agglutinin and Solanum tuberosum agglutinin by sugar-specific interaction. The glycosaminoglycans showed different inhibitory activities to the hemagglutination reaction of these lectins and keratan sulfate and its modif...
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We have characterized sulfated glycosaminoglycans from ovaries of the blood-sucking insect Rhodnius prolixus, and determined parameters of their synthesis and distribution within this organ by biochemical and histochemical procedures. The major sulfated glycosaminoglycan is heparan sulfate while chondroitin 4-sulfate is a minor component. These glycosaminoglycans are concentrated in the ovarian...
متن کاملIncreased deposition of sulfated glycosaminoglycans in human patellar tendinopathy.
OBJECTIVE To investigate if the increased proteoglycans in patellar tendinopathy involves a qualitative change in the types of proteoglycans. DESIGN This is an observational study based on the biochemical analysis of proteoglycans. SETTING : University Teaching Hospital. PATIENTS Patellar tendon samples from 12 patients with patellar tendinopathy and 12 healthy controls were collected and...
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Human scleras were analyzed to determine if tissue hydration changed in an age-related fashion, and whether this change could be related to decreased levels of glycosaminoglycans. The anterior half of normal human scleras were examined with donor ages ranging from newborn to 99 years (n = 40). Tissue hydration was found to decrease by 1.06% per decade (P = 0.0012). Glycosaminoglycans were extra...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2002
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.122.435