Biosynthesis of Sphingolipid Bases
نویسندگان
چکیده
منابع مشابه
Biosynthesis of unsaturated sphingolipid bases by microsomal preparations from oysters.
A cell-free particulate preparation from oyster viscera incorporated [r4C]palmitate and [r4C]serine into the long chain base sphingadienine. Both double bonds of the product were shown to have the frans configuration. frans2-Hexadecenoic and frans-6-hexadecenoic acids were not effective in decreasing the incorporation of the radioactive label from palmitate, nor was label from palmitate incorpo...
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Sphingolipid biosynthesis was studied in cultured murine cerebellar cells in the absence and presence of exogenous sphingosine homologues with different alkyl chain lengths (12, 18, and 24 carbon atoms). Labeling of cells with [14C]serine for 24 h indicated that endogenous sphingosine biosynthesis with incorporation of radiolabeled serine was inhibited by these long chain bases (0.5-50 microM) ...
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A hypothesis by B e r n h a u e r on the biosynthesis of the benzimidazole bases of corrinoids implicates the possible existence of a corrinoid containing 6',7'-dimethylnaphtho(2',3') -imidazole4,5 (DMNIA). In order to facilitate the detection of this corrinoid in natural sources by means of a reference compound, DMNIA was synthesized and added to cultures of Propionibacterium shermanii. Thus t...
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The ability of phagocytes to clear pathogens is an essential attribute of the innate immune response. The role of signaling lipid molecules such as phosphoinositides is well established, but the role of membrane sphingolipids in phagocytosis is largely unknown. Using a genetic approach and small molecule inhibitors, we show that phagocytosis of Candida albicans requires an intact sphingolipid b...
متن کاملTotal synthesis of the sphingolipid biosynthesis inhibitor fumonisin B(1).
The first total synthesis of the sphingolipid biosynthesis inhibitor fumonisin B(1) has been achieved. This convergent synthesis utilizes oxonia Cope rearrangements to prepare two key homoallylic alcohols, which are then functionalized to the primary components A and B for cross-coupling. Other highlights of our approach include a new and efficient synthesis of the diprotected tricarballylic ac...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1969
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)94455-8