Biopsy diagnostics in renal allograft rejection: from histomorphology to biological function
نویسندگان
چکیده
منابع مشابه
Mechanisms of Renal Allograft Rejection
Rejection is the major cause of graft failure, and if the injury to the tubules and glomeruli is severe, the kidney may not recover. It is therefore important to diagnose acute rejection as soon as possible to institute prompt antirejection therapy. Generally, the success with which rejection can be reversed by immunosuppressive agents determines the chance of long-term success of the transplan...
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Twenty-two recipients of HLA-nonidentical living related and nonrelated renal allografts were studied for alterations in the relative percentage of OKT4-positive peripheral blood T-cells after transplantation. Characteristic shifts in the ratio of T-helper to T -suppressor/cytotoxic cells (TH/TS-C), but not absolute cell numbers, were demonstrated to correspond with the status of the allog...
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Features of rejection were found in 21 needle biopsies obtained from seven patients after liver transplantation. Wedge biopsies taken peroperatively were used as a baseline for comparison. Rejection was diagnosed by excluding other known causes of graft dysfunction using appropriate methods. In cases in which these criteria were fulfilled a consistent picture of rejection was seen, and this was...
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ژورنال
عنوان ژورنال: Transplant International
سال: 2009
ISSN: 0934-0874,1432-2277
DOI: 10.1111/j.1432-2277.2009.00885.x