Biomolecular Chemistry of Isopropyl Fibrates

Organic and Biomolecular Chemistry

International Union of Pure and Applied Chemistry Organic and Biomolecular Chemistry Division* Subcommittee on Biomolecular Chemistry** Protocols on Safety, Efficacy, Standardization, and Documentation of Herbal Medicine

This Technical Report compiles and analyzes the current scientific knowledge on herbal medicine and highlights the practical ways for ensuring the safety of herbal preparations and evaluating their claimed efficacy. Emphasis has been given to the methods for standardization of herbal medicine and the ways and means for moving forward to achieve the difficult goal of preparing herbal medicines o...

Organic & Biomolecular Chemistry 12(21):3371-3379 doi:10.1039/C4OB00230J

From supramolecular chemistry to the nucleosome: studies in biomolecular recognition

This review highlights the author's indirect path to research at the interface of supramolecular chemistry and chemical biology.

Fibrates and cholestasis.

Cholestasis, including primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), results from an impairment or disruption of bile production and causes intracellular retention of toxic bile constituents, including bile salts. If left untreated, cholestasis leads to liver fibrosis and cirrhosis, which eventually results in liver failure and the need for liver transplantation. Cur...