منابع مشابه
Pairing Cancer Biomarkers to Biomedicine
On May 23, 2017, the US Food and Drug Administration (FDA) approved pembrolizumab for the treatment of any solid tumors with certain specific genetic features or biomarkers, namely microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR). This was the first time that the FDA approved a cancer treatment based on a common biomarker, rather than the organ site or histology. Pemb...
متن کاملNatural born killers.
This year, 30 million acres of the corn, cotton, and potatoes planted in the United States will have been genetically engineered to produce an endotoxin normally found in the microbe Bacillus thuringiensis (Bt), a self-contained pesticide that will be toxic only to target insects. Transgenic pest-resistant crops are a cost-effective alternative to chemical pesticides, and may offer a way to hel...
متن کاملNatural born killers: NK cells drafted into the cancer fight.
Once thought of as foot soldiers in the body's fight against cancer, natural killer (NK) cells are more akin to special forces in bolstering the immune system to respond to foreign invaders. New studies are revealing that rather than randomly killing cells—as was thought for many years—NK cells are programmed to seek out specific targets on cancer cells. " For the past 25 years, we have been so...
متن کاملTrace Evidence: Identifying Natural Cancer Killers After the Crime
Article history: Received 7 September 2015 Received in revised form 15 September 2015 Accepted 15 September 2015 Available online 24 September 2015 the patient's leukemia type, most likely mediated by trogocytosis (Somanchi et al., 2012), suggesting recent interaction with the leukemia cells and possible anti-leukemic activity. It is important to note that although the patients have this activa...
متن کاملReinforcing natural killers.
weight to a finding published a decade ago by the group at St Jude Children’s Research Hospital. That finding stated that patients with low TPMT activity receiving 6-MP in combination with radiotherapy have increased risk of SMNs.6 The paper leaves many questions unanswered. Whether this association is caused by 6-MP therapy alone or whether high-dose MTX given along with 6-MP in maintenance co...
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ژورنال
عنوان ژورنال: Science
سال: 2005
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.308.5729.1715c