Biomarkers in biological fluids for dementia with Lewy bodies
نویسندگان
چکیده
منابع مشابه
Cerebrospinal Fluid Biomarkers for Dementia with Lewy Bodies
More than 750,000 of the UK population suffer from some form of cognitive impairment and dementia. Of these, 5-20% will have Dementia with Lewy Bodies (DLB). Clinico-pathological studies have shown that it is the low frequency of DLB clinical core features that makes the DLB diagnosis hardly recognisable during life, and easily misdiagnosed for other forms of dementia. This has an impact on the...
متن کاملDementia with Lewy bodies.
The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neuroc...
متن کاملDementia with Lewy bodies.
Dementia with Lewy bodies (DLB) is the second most common diagnosis of dementia after Alzheimer disease (AD). The essential pathologic feature is the Lewy body, a neuronal inclusion containing α-synuclein, found in brainstem nuclei and the neocortex. Clinical features include early fluctuations in attention, hallucinations, and parkinsonism, with progression to a combined cortical and subcortic...
متن کاملDementia with Lewy bodies.
In the last decade, a new degenerative dementia, probably the second most common after Alzheimer's disease (AD), has been increasingly recognized under the consensus name of dementia with Lewy bodies (DLB). This article reviews current clinical, genetic, and pathological DLB data and indicates directions for future research. DLB overlaps in clinical, pathological, and genetic features with AD a...
متن کاملDementia with Lewy bodies.
DLB is one of several causes of dementia. The most common cause is Alzheimer's disease, which is an entirely separate neurodegenerative disease. Vascular dementia is the second most common cause of dementia, and here the pathological changes are due to stroke and to related changes that impair blood circulation in the brain. DLB is the third most common cause. Changes of all three disorders can...
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ژورنال
عنوان ژورنال: Alzheimer's Research & Therapy
سال: 2014
ISSN: 1758-9193
DOI: 10.1186/s13195-014-0072-3