منابع مشابه
Fibroblasts, myofibroblasts, and wound contraction
clinical case reconstructed by Guido Majno (1975) from the Hippocratic records describes a wrestler who visits the iatreion (out-patient clinic) to be treated for a shoulder dislocation. With less invasive procedures no longer working to tighten the dislocation, the clinic adopts the drastic measure of inducing wound contraction by poking a hot needle through the skin of the armpit, and "in thi...
متن کاملFibroblasts and myofibroblasts in wound healing
(Myo)fibroblasts are key players for maintaining skin homeostasis and for orchestrating physiological tissue repair. (Myo)fibroblasts are embedded in a sophisticated extracellular matrix (ECM) that they secrete, and a complex and interactive dialogue exists between (myo)fibroblasts and their microenvironment. In addition to the secretion of the ECM, (myo)fibroblasts, by secreting matrix metallo...
متن کاملPhenoconversion of Cardiac Fibroblasts to Myofibroblasts
The cardiac stroma provides tensile strength binding muscle cells and serves as structural scaffolding in the presence of continuous cyclic changes in mechanical tension. The principal stromal cell types are fibroblasts, but this designation belies their diversity and topographical differentiation from organ to organ, including the heart.1 For example, skin fibroblasts and vascular smooth muscl...
متن کاملDistinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progression and therapeutic response in pancreatic ductal adenocarcinoma (PDA). However, it is unknown whether CAFs uniformly carry out these tasks or if subtypes of CAFs with distinct phenotypes in PDA exist. We identified a CAF subpopulation wit...
متن کاملChloride channel activity in human lung fibroblasts and myofibroblasts.
It is well established that transforming growth factor (TGF)-beta stimulates human lung fibroblasts (HLF) to differentiate into myofibroblasts. We characterized lysophosphatidic acid (LPA)-activated Cl- channel current (I(Cl-LPA)) in cultured human lung fibroblasts and myofibroblasts and investigated the influence of I(Cl-LPA) on fibroblast-to-myofibroblast differentiation. We recorded I(Cl-LPA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the American Thoracic Society
سال: 2008
ISSN: 1546-3222
DOI: 10.1513/pats.200708-146dr