Biologic Agents for the Treatment of Hypereosinophilic Syndromes
نویسندگان
چکیده
منابع مشابه
Imatinib mesylate for the treatment of hypereosinophilic syndromes.
Hypereosinophilic syndromes (HES) define several distinct entities, all of which show blood and tissue hypereosinophilia and end-organ secondary manifestations. From a clinical and pathogenic perspective, the best characterized are the myeloproliferative and lymphoproliferative variants. While there are several therapies available for the treatment of HES, such as corticosteroids, IFNalpha and ...
متن کاملHypereosinophilic syndromes
Hypereosinophilic syndromes (HES) constitute a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia (> 1.5 x 10(9)/L for more than six consecutive months) associated with evidence of eosinophil-induced organ damage, where other causes of hypereosinophilia such as allergic, parasitic, and malignant disorders have been excluded. Prevalence is unknown. HES...
متن کاملRecent advances in the diagnosis and treatment of hypereosinophilic syndromes.
Hypereosinophilic syndromes (HES) are a heterogeneous group of disorders characterized by marked peripheral blood and tissue eosinophilia resulting in end organ damage. Recent advances in molecular biology and immunology have led to the identification of a number of distinct subtypes of HES with differing epidemiology, pathogenesis, and prognosis. The ability to distinguish between these HES su...
متن کاملHow I treat hypereosinophilic syndromes.
Hypereosinophilic syndromes (HESs) are a heterogeneous group of uncommon disorders characterized by marked peripheral eosinophilia and end organ manifestations attributable to the eosinophilia or unexplained in the clinical setting. Whereas corticosteroids remain the mainstay of treatment for most patients, recent diagnostic advances and the development of novel targeted therapies, including ty...
متن کاملHow I Diagnose Hypereosinophilic Syndromes
Hypereosinophilic syndromes are a group of disorders characterised by significant eosinophilia and organ damage. They have proven challenging to define, diagnose, and study for many years, due in part to their variable clinical presentations, the overlap between neoplastic and reactive eosinophilia, and the lack of a universal marker of eosinophil clonality. Herein, we give an overview of the t...
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ژورنال
عنوان ژورنال: The Journal of Allergy and Clinical Immunology: In Practice
سال: 2017
ISSN: 2213-2198
DOI: 10.1016/j.jaip.2017.08.001