Biohydrogel Based on Dynamic Covalent Bonds for Wound Healing Applications

Development of antimicrobial chitosan based nanofiber dressings for wound healing applications

Objective(s): Chitosan based composite fine fibers were successfully produced via a centrifugal spinning technology. This study evaluates the ability of the composites to function as scaffolds for cell growth while maintaining an antibacterial activity. Materials and methods: Two sets of chitosan fiber composites were prepared, one filled with anti-microbial silver nanoparticles and another on...

Functional systems with orthogonal dynamic covalent bonds.

This review summarizes the use of orthogonal dynamic covalent bonds to build functional systems. Dynamic covalent bonds are unique because of their dual nature. They can be as labile as non-covalent interactions or as permanent as covalent bonds, depending on conditions. Examples from nature, reaching from the role of disulfides in protein folding to thioester exchange in polyketide biosynthesi...

Designing polysaccharide-based antibacterial biomaterials for wound healing applications

In this study, the development and characterization of novel polymer blends based on chitosan-poly (vinyl alcohol) and physically cross-linked by freeze-thaw method for possible use in a variety of biomedical application is reported. The present investigation deals with designing savlon-loaded blend hydrogels (coined as cryogels) of poly (vinyl alcohol) (PVA) and chitosan by repeated freeze-tha...

Self-healing and Mechanochromism of Diarylbibenzofuranone-based Dynamic Covalent Polymers

Covalent bonds with the ability to reach an equilibrium state between combination and dissociation under certain conditions have been studied, and systematic method for controlling the structures of compounds and polymers based on these reversible covalent bonds has been spotlighted as dynamic covalent chemistry. In the present study, diarylbibenzofuranone (DABBF)-based dynamic covalent polymer...

Covalent Bonds